Enzymes of mercapturate synthesis and other drug-metabolizing reactions-specific localization in the eye
Identifieur interne : 000261 ( an2020/Analysis ); précédent : 000260; suivant : 000262Enzymes of mercapturate synthesis and other drug-metabolizing reactions-specific localization in the eye
Auteurs : Noveen D. Das [États-Unis] ; Hitoshi Shichi [États-Unis]Source :
- Experimental Eye Research [ 0014-4835 ] ; 1981.
English descriptors
- Teeft :
- Aminopeptidase, Aromatic hydrocarbons, Aryl, Aryl hydrocarbon hydroxylase, Aryl hydrocarbon hydroxylase system, Assay, Ciliary, Ciliary body, Cystine, Cystine aminopeptidase, Cytosolic enzyme, Drug metabolism, Drug metabolizing enzymes, Endoplasmic, Endoplasmic reticulum, Enzyme, Enzyme activities, Enzyme protein, Epithelium, Genetic differences, Glutathione, Glutathione conjugates, Hydrocarbon, Hydroxylase, Important role, Isopycnic centrifugation, Melanin granules, Mercapturate, Mercapturate synthesis, Metabolism, Metabolizing, Microsomal, Microsome, Nebert, Ocular, Ocular tissues, Reticulum, Retina, Shichi, Transferase, Transferase activities, Transpeptidase.
Abstract
Distribution of arylhydrocarbon hydroxylase and UDP-glucuronyl transferase activities in bovine ocular tissues indicates that the drug-metabolizing enzyme activities are highest in the ciliary body, followed by the pigmented epithelium-choroid and iris. Retina, lens and cornea show little or no activities. The activities of enzymes involved in mercapturate synthesis (gamma-glutamyl transpeptidase, cystine amino-peptidase, and N-acetyl transferase) are also associated with the microsomal fraction of these tissues. Isopycnic centrifugation of the microsomes indicates that glutathione S-transferase, gamma-glutamyl transpeptidase and cytine aminopeptidase, are associated with the same membrane, while N-acetyl transferase is not. The association of the drug-metabolizing enzymes with the ciliary body and pigmented epithelium-choroid, both being in contact with the uveal blood circulation, supports the view that these enzymes will play an important role in the detoxification of blood nutrients which are required for the specific functions of these tissues.
Url:
DOI: 10.1016/S0014-4835(81)80127-3
Affiliations:
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Retina, lens and cornea show little or no activities. The activities of enzymes involved in mercapturate synthesis (gamma-glutamyl transpeptidase, cystine amino-peptidase, and N-acetyl transferase) are also associated with the microsomal fraction of these tissues. Isopycnic centrifugation of the microsomes indicates that glutathione S-transferase, gamma-glutamyl transpeptidase and cytine aminopeptidase, are associated with the same membrane, while N-acetyl transferase is not. The association of the drug-metabolizing enzymes with the ciliary body and pigmented epithelium-choroid, both being in contact with the uveal blood circulation, supports the view that these enzymes will play an important role in the detoxification of blood nutrients which are required for the specific functions of these tissues.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Das, Noveen D" sort="Das, Noveen D" uniqKey="Das N" first="Noveen D." last="Das">Noveen D. Das</name></noRegion><name sortKey="Shichi, Hitoshi" sort="Shichi, Hitoshi" uniqKey="Shichi H" first="Hitoshi" last="Shichi">Hitoshi Shichi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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